Cellular Reprogramming Unit
The Cellular Reprogramming Unit uses cell reprogramming and stem cell technologies to better understand and develop treatments for eye diseases, with the goal of regenerating cells in the eye.
We are located at the Centre for Eye Research Australia and Department of Surgery (Ophthalmology), University of Melbourne, Australia.
The Cellular Reprogramming Unit is devoted to developing regenerative therapies and gene therapies to treat retinal degeneration. In our research, we work with advanced techniques such as direct reprogramming, human induced pluripotent stem (iPS) cells, CRISPR/Cas9 gene editing and single cell transcriptomics. Our goal is to better understand and control cell fate decisions in the eye. This allows us to develop new ways to generate human retinal cells in the lab, which can be used to study the mechanism underlying retinal diseases, tissue engineering and transplantation.
Latest Publications &
Development of a CRISPRi human retinal pigmented epithelium model for functional study of age-related macular degeneration genes
Wang J., Urrutia-Cabrera D., Lees J., Mora S., Nguyen T., Hung S., Hewitt A., Lim S., Edwards T., Wong R. (2023) Development of a CRISPRi human retinal pigmented epithelium model for functional study of age-related macular degeneration genes, International Journal of Molecular Sciences, accepted 2023.02.04 (IF = 6.21)