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Full list of publications and preprints available in ORCID, Google Scholar and ResearchGate

Last updated 14-Mar-2024



  1. Wang L, Hung S, Urrutia-Cabrera D, Kong R, Staffieri S, Ludlow L, Lau X, Wang PY, Hewitt A, Wong R (2024) Spatial transcriptomic profiling of human retinoblastoma. bioRxiv, doi: 10.1101/2024.02.05.578886 [Link]

  2. Liu R, Urrutia-Cabrera D, Westin, I, Golovleva I, Liu G, Kumar S, McLenachan S, Chen F, Hsu F, Edwards T, Martin K, Cheng A, Wong R (2024) Using RNA-targeting CRISPR-Cas13 and engineered U1 systems to reduce ABCA4 splice variants in Stargardt disease. bioRxiv, doi: [Link]

  3. Pasvanis Z, Boynes A, Kong R, Chan E, Wong R, Fan Gaskin J (2024) Transcriptomic analysis of TGFB-mediated fibrosis in primary human Tenon’s fibroblasts. bioRxiv, doi: [Link]



  1. Song JN, Liu K, Mei J, Wang L, Lin J, Du P, Liu YC, Wan Y, Wong R, Yin YU, Wang PY (2023) Defined Surface Physicochemical Cues Inhibit M1 Polarization of Human Macrophages Using Colloidal Self-Assembled Patterns. ACS Applied Materials & Interfaces, 2023, 15, 30, 35832-35846 (IF = 10.38) [Link]

  2. Wang, J., Wong, R., Liu G. (2023) Retinal aging transcriptome and cellular landscape in association with the progression of age-related macular degeneration. Investigative Ophthalmology & Visual Science, 2023 Apr; 64(4): 32 (IF = 4.93) [Link]

  3. Harati J., Liu K., Shahsavarani H., Du P., Galluzzi M., Deng K., Mei J., Chen HY., Bonakdar S., Aflatoonian B., Hou G., Zhu Y., Pan H., Wong R., Shokrgozar M., Song W., Wang P. (2023) Defined physiochemical cues steering direct neuronal reprogramming on colloidal self-assembled patterns (cSAPs). ACS Nano, 2023, 17, 2, 1054-1067 (IF = 18.03) [Link]

  4. Wang J., Urrutia-Cabrera D., Lees J., Mora S., Nguyen T., Hung S., Hewitt A., Lim S., Edwards T., Wong R. (2023) Development of a CRISPRi human retinal pigmented epithelium model for functional study of age-related macular degeneration genes, International Journal of Molecular Sciences, 2023, 24(4), 3417 (IF = 6.21) [Link]

  5. Nguyen T., Urrutia-Cabrera D., Wang L., Lees J., Wang J., Hung S., Hewitt A., Edwards T., McLenachan S., Chen F., Lim S., Luu C., Guymer R., Wong R. (2023) Knockout of AMD-associated gene POLDIP2 reduces mitochondrial superoxide in human retinal pigment epithelial cells. Aging, 2023 Feb 16; 15(6): 1713-1733 (IF = 5.96) [Link]

  6. Tribble J., Hagstrom A., Jusseaume K., Lardner E., Wong R., Stalhammar G., Williams P. (2023) NAD salvage pathway machinery expression in normal and glaucomatous retina and optic nerve. Acta Neuropathologica Communications, 2023 Jan 22; 11(1):18 (IF =  7.58) [Link]



  1. Wang, J., Wong, R., Liu G. (2022) Retinal aging transcriptome and cellular landscape in association with the progression of age-related macular degeneration. medRxiv, doi: 10.1101/2022.04.03.22273375 [Link]

  2. Nguyen T., Urrutia-Cabrera D., Wang L., Lees J., Wang J., Hung S., Hewitt A., Edwards T., Lim S., Luu C., Guymer R., Wong R. (2022) Knockout of AMD-associated gene POLDIP2 reduces mitochondrial superoxide in human retinal pigment epithelial cells. bioRxiv doi: 10.1101/2022.07.05.498910 [Link]

  3. Wang, J., Wong, R., Liu G. (2022) Retinal transcriptome and cellular landscape in relation to the progression of diabetic retinopathy. medRxiv, doi: 10.1101/2022.05.05.22274746v1 [Link]


  1. Wang. J., Lidgerwood, G., Daniszewski, M., Lu, M., Roberts, G., Wong, R., Hung, S., McClements, M., Hewitt, A., Pebay, A., Hickey, D., Edwards, T. (2022) AAV2-mediated gene therapy for Bietti crystalline dystrophy provides functional CYP4V2 in multiple relevant cell models. Scientific Reports, 2022 Jun 9; 12(1):9525 (IF = 5) [Link]

  2. Wang, J., Chuang Y, Chen J., Zhu L., Singh V, Lin F, Wilson R, Tu L, Ma C., Wong R., Wang P., Zhong J., Hewitt A., Van Wijngaarden P., Dusting G., Liu G. (2022) An integrative multi-omics analysis reveals microRNA-143 as potential therapeutics to attenuate retinal angiogenesis. Nucleic Acid Therapeutics, 2022 Aug; 32(4):251-266 (IF=4.24) [Link]

  3. Urrutia-Cabrera, D., Liou, R., Lin, J., Shi, Y., Liu, K., Hung, S., Hewitt, A., Wang, P.Y., Wong, R. (2022) Combinatorial application of binary colloidal crystals and CRISPR activation to improve induced pluripotent stem cell differentiation into neurons, ACS Applied Materials & Interfaces, 14, 7, 8669-8679 (IF = 10.38) [Link]

  4. Wang, J., Wong, R., Liu G. (2022) Retinal transcriptome and cellular landscape in relation to the progression of diabetic retinopathy. Investigative Ophthalmology & Visual Science, 2022 Aug; 63(9):26 (IF = 4.93) [Link]



  1. Lin F., Wang, J., Chen J., Zhu L., Chuang Y., Ma C., Lama S., Ling D., Wong R., Hewitt A., Tseng CL, Bui B., Van Wijngaarden P., Dusting G., Wang P., Liu G. (2021) TAK1 blockade as a therapy for retinal neovascularization. bioRxiv, doi: 10.1101/2021.01.29.428701 [Link]


  1. Wong R., Huang J, Li D, Amaral O (2021) Editorial: Somatic cell gene editing for treating diseases, Frontiers in Cell and Developmental Biology, accepted 2021.12.04 (IF = 6.08) [Link]

  2. Du, P., Tao, X, Liu, K., Lin, J., Shi, Y., Deng, K., Park, K., Chen, H.Y., Zhang, Z., Lin, C.P., Chang, J., Wong, R., Wang, P.Y. (2021) Human platelet lysate (hPL) alters the lineage commitment and paracrine functions of human mesenchymal stem cells via mitochondrial metabolism. Applied Materials Today, in press. (IF = 8.66) [Link]

  3. Urrutia-Cabrera, D., Liou, R., Wang, J., Chan, J., Hung, S., Hewitt, A., Martin, K., Edwards, T., Kwan, P., Wong, R. (2020) Comparative analysis of loop-mediated isothermal amplification (LAMP)-based assays for rapid detection of SARS-CoV-2, Scientific Reports, 11: 22493 (IF = 5) [Link]

  4. Wong R., Hasagawa K., Peh G., Liu GS. (2021) Editorial: Advances in cell and gene therapy in treating neural diseases, Frontiers in Cellular Neuroscience, accepted 2021.10.19 (IF = 6.15) [Link]

  5. Gautam, P., Hamashima, K., Chen, Y., Zeng, Y., Makovoz, B., Parikh, B., Lee, H., Lau, K., Su, X., Wong, R., Chan, K., Li, H., Blenkinsop, T., Loh, Y. (2021) Multi-species single-cell transcriptomic analysis of ocular compartment regulons, Nature Communications, 2021 Sep 28; 12(1):5675 (IF=17.7) [Link]



  1. Urrutia-Cabrera, D., Liou, R., Hung, S., Hewitt, A., Wang, P.Y., Wong, R. (2020) Combinatorial application of binary colloidal crystals biomaterial and CRISPR activation system to direct pluripotent stem cell differentiation into neurons, bioRxiv,  doi: [Link]

  2. Wang, J., Urrutia-Cabrera, D., Mora, S., Nguyen, T., Hung, S., Hewitt, A., Edwards T., Wong, R. (2020) Functional study of the AMD-associated gene TMEM97 in retinal pigmented epithelium using CRISPR interference, bioRxiv, doi: [Link]
  3. Urrutia-Cabrera, D., Liou, R., Chan, J., Hung, S., Hewitt, A., Martin, K., Kwan, P., Wong, R. (2020) Comparative analysis of loop-mediated isothermal amplification (LAMP)-based assays for rapid detection of SARS-CoV-2, medRxiv, doi: [Link]



  1. Nguyen, T., Urrutia-Cabrera, D., Liou, R., Luu, C., Guymer, R., Wong, R. (2020) New technologies to study functional genomics of age-related macular degeneration, Frontiers in Cell and Developmental Biology, 2021 Jan 11;8:604220 (IF = 6.08) [Link]

  2. Li, F., Wing, K., Wang, J., Luu, C., Bender, J., Chen, J., Wang, Q., Lu, Q., Tran, M., Young, K., Wong, R., Pebay, A., Cook, A., Hung, S., Liu, G.S., Hewitt, A. (2020) Comparison of CRISPR/Cas endonucleases for in vivo retinal gene editing. Frontiers of Cellular Neurosciences, 2020; 14: 570917 (IF = 6.15) [Link]

  3. Liou, R., Edwards, T., Martin, K., Wong, R. (2020) Neuronal reprogramming for tissue repair and neuroregeneration. International Journal of Molecular Sciences, 2020 Jun 16;21(12):E4273 (5 yr IF=6.21) [Link]

  4. Kompa, A., Greening, D., Kong, A., McMillan, P., Fang, H., Saxena, R., Wong, R., Lees, J., Sivakumaran, P., Newcomb, A., Cabrera-Fuentes, H., Tannous, B., Kos, C., Mariana, L., Loudovaris, T., Hausenloy, D., Lim, S.Y. (2020) Sustained subcutaneous delivery of scretome of human cardiac stem cells promote cardiac repair following myocardial infarction. Cardiovascular Research, 2020 Apr 6; cvaa088 (IF=13.08) [Link]

  5. Urrutia-Cabrera, D., Wong, R. (2020) Using single cell transcriptomics to study the complexity of human retina. Neural Regeneration Research, 15(11):2045-2046 (IF = 6.06) [Link]


  1. Chung, S., Shen, W., Davidson, K., Pebay, A., Wong, R, Yau, B., Gillies, M. (2019) Differentiation of retinal  glial cells from human embryonic stem cells by promoting the Notch signaling pathway. Frontiers in Cellular Neuroscience, 2019 Dec 3; 13:527 (IF = 6.15) [Link]

  2. Lukowski, S*, Lo, C.*, Sharov, A., Nguyen, Q., Fang, L., Hung, S., Zhu, L., Zhang, T., Grünert, U., Nguyen, T., Senabouth, A., Jabbari, J., Welby, E., Sowden, J., Waugh, H., Mackey, A., Pollock, G., Lamb, T., Wang, P.Y., Hewitt, A., Gillies, M., Powell, J.#, Wong, R.# (2019) A single-cell transcriptome atlas of the adult human retina. EMBO Journal, e100811 (IF = 14.01)  [Link]

  3. Wazan, L., Urrutia-Cabrera, D., Wong, R. (2019) Using transcription factors for direct reprogramming of neurons in vitro, World Journal of Stem Cells, 11(7): 431-444 (IF=5.25) [Link]

  4. Fan, L., Hung, S., Wang, J.H., Chrysostomou, V., Wong, V., Bender, J., Tu, L., Pebay, A., King, A., Cook, A., Wong, R., Bui, B., Hewitt, A., Liu, G. (2019) Utility of self-destructing CRISPR/Cas constructs for targeted gene editing in the retina. Human Gene Therapy, 2019 Nov; 30(11):1349-1360. (IF = 4.79) [Link]

  5. Tran, M., Khalid, M., Pebay, A., Cook, A., Lian, H., Wong, R., Craig, J., Liu, G.S., Hung, S., Hewitt, A. (2019) Screening of CRISPR/Cas base editors to target the AMD high-risk Y402H complement factor H variant, Molecular Vision, 25:174-182. (IF = 2.71) [Link]

  6. Fang, L.*, Hung, S.*, Yek, J., Nguyen, T., Khan, S., Hewitt, A., Wong, R. (2019) A simple cloning-free method to efficiently induce gene expression using CRISPR/Cas9. Molecular Therapy -Nucleic Acids, 14: 184-191, Mar 01, 2019. (IF = 10.18) [Link]


  1. Fang, L., Wazan, L., Tan, C., Nguyen, T., Hung, S., Hewitt, A., Wong, R. (2018) Potentials of cellular reprogramming as a novel strategy for regenerative medicine. Frontiers in Cellular Neuroscience, 2018 Nov 30; 12:460. (IF = 6.15) [Link]

  2. Hoque, A., Sivakumaran, P., Bond, S., Scott, J., Bandara, N., Hernandez, D., Liu, G.S., Wong, R., Ryan, M., Hausenloy, D., Kemp, B., Oakhill, J., Drew, B., Pebay, A., Lim, S.Y. (2018) Inhibiting mitochondrial fission protein Drp1 directs cardiac mesodermal differentiation of human pluripotent stem cells. Cell Death Discovery, 2018 Mar 5; 4:39 (IF = 7.13) [Link]

  3. Wong, R., Pera, M., Pébay, A. (2018) Maintenance of human embryonic stem cells by sphingosin-1-phostate and platelet-derived growth factor. Methods in Molecular Biology, 2018;1697:133-140. [Link]

  4. Fang, L., Ding, Y., Liang, H., Wong, R. (2018) Using cellular reprogramming technology and induced pluripotent stem cells to study and treat retinal diseases. Chinese Journal of Experimental Ophthalmology, 36 (11). [Link]

  5. Wang, P.Y., Khan, S., Nguyen, T., Kingshott, P., Wong, R. (2018) Topographical modulation of pluripotency and differentiation of human embryonic stem cells. IEEE Transactions on Nanotechnology, 17(3), May 2018, 381-384 (IF = 2.97). [Link]


​Edited book:

  1. Stem Cell Biology and Regenerative Medicine: Lipidomics of Stem Cells (2017) Springer Nature Press. Pébay, A. & Wong, R. (Editors).

Journal publications:

  1. Wang, P.Y., Ding, S., Sumer, H., Wong, R., Kingshott, P. (2017) Heterogeneity of mesenchymal and pluripotent stem cell populations grown on nanogroves and nanopillars. Journal of Materials Chemistry B, 5, 7927-7938. (IF = 7.57) [Link]

  2. Galloway, C., Dalvi, S., Hung, S., MacDonald, L., Latchney, L., Wong, R., Guymer, R., Mackey, D., Williams, D., Chung, M., Gamm, D., Pebay, A., Hewitt, A., Singh, R. (2017) Drusen in patient-derived hiPSC-RPE models of macular dystrophies. Proceedings of the National Academy of Sciences – USA, 114(39): E8214-E8223 (IF = 12.78) [Link]

  3. Nguyen, T., Wong, R. (2017) Neuroregeneration using in vivo cellular reprogramming. Neural Regeneration Research, 12(7): 1073-1074 (IF = 6.06) [Link]

  4. Crombie, D., Curl, C., Raaijmakers, H., Sivakumaran, P., Kulkarni, T., Wong, R., Minami, I., Evans-Galea, M., Lim, S.Y., Delbridge, L., Corben, L., Dottori, M., Nakatsuji, N., Trounce, I., Hewitt, A., Delatycki, M., Pera, M., Pébay, A. (2017) Friedreich's ataxia induced pluripotent stem cell-derived cardiomyocytes display electrophysiological abnormalities and calcium handling deficiency. Aging, 9(5):1440-1452 (IF = 5.96) [Link]

  5. Wong, R., Hung, S., Jackson, S., Singh, V., Khan, S., Liang, H., Kearns, L., Nguyen, T., Conquest, A., Daniszewski, M., Hewitt, A., Pébay, A. (2017) Generation of a human induced pluripotent stem cell line CERAi001-A-6 using episomal vectors. Stem Cell Research, 22(2017): 13-15 (IF = 1.59) [Link]

  6. Daniszewski, M., Crombie, D., Henderson, R., Liang, H., Wong, R., Hewitt, A., Pébay, A. (2017) Automated Cell Culture Systems and their Applications to Human Pluripotent Stem Cell Studies. SLAS Technology, 2017 Jun 1:247263031771222. (IF = 2.81) [Link]

  7. Wong, R., Lim, S., Hung, S., Jackson, S., Khan, S., Van Bergen, N., De Smit, E., Liang, H., Kearns, L., Clarke, L., Mackey, D., Hewitt, A., Trounce, I., Pebay, A. (2017) Mitochondrial replacement in an iPSC model of Leber’s Hereditary Optic Neuropathy, Aging, 9(4):1341-1350 (IF = 5.96) [Link]

  8. Crombie, D.*, Daniszewski, M.*, Liang, H., Kulkarni, T., Li, F., Lidgerwood, G., Conquest, A., Hernandez, D., Hung, S., Gill, K., De Smit, E., Kearns, L., Clarke, L., Sluch, V., Chamling, X., Zack, D., Wong, R., Hewitt, A., Pebay, A. (2017) Development of a modular automated system for maintenance and differentiation of adherent human pluripotent stem cells., SLAS Discovery, 2017 Mar 1:2472555217696797 (IF = 3.34) [Link]

  9. Hung, S., Khan, S., Lo, C., Hewitt, A., Wong, R. (2017) Drug discovery using induced pluripotent stem cell models of neurodegenerative and ocular diseases. Pharmacology and Therapeutics, pii: S0163-7258(17)30040-2. (IF = 13.4) [Link]


  1. Wang, P.Y., Hung, S., Thissen, H., Kingshott, P., Wong, R. (2016) Binary colloidal crystals (BCCs) as a feeder-free system to generate human induced pluripotent stem cells (hiPSCs). Scientific Reports, 2016 Nov 11;6:36845 (IF = 5) [Link]

  2. Khan, S., Hung, S., Wong, R. (2016) The use of induced pluripotent stem cells for studying and treating optic neuropathies. Current Opinion in Organ Transplantation, 2016 Oct;21(5):484-9. (IF = 2.27) [Link]

  3. Gill, K.*, Hung, S.*, Sharov, A., Lo, C., Needham, K., Lidgerwood, G., Jackson, S., Crombie, D., Nayagam, B., Cook, A., Hewitt, A., Pébay, A.#, Wong, R.# (2016) Enriched retinal ganglion cells derived from human embryonic stem cells. Scientific Reports, 2016 Aug 10;6:30552.  (IF = 5) [Link]

  4. Hung, S., Chrysostomou, V., Li, F., Lim, J., Wang, J.H., Powell, J., Tu, L., Daniszewski, M., Lo, C., Wong, R., Crowston, J., Pébay, A., King, A., Bui, B., Liu, G.S., Hewitt, A. (2016) AAV-mediated CRISPR/Cas gene editing of retinal cells in vivo. Investigative Ophthalmology & Visual Science, 57(7):3470-6 (IF = 4.93) [Link]

  5. Hung, S., Van Bergen, N., Jackson, S., Liang, H., Mackey, D., Hernandez, D., Lim, S.Y., Hewitt, A., Trounce, I., Pébay, A., Wong, R. (2016) Study of mitochondrial respiratory defects on reprogramming to human induced pluripotent stem cells. Aging, 8(5):945-57 (IF = 5.96) [Link]

  6. Phelan, D., Anderson, D., Howden, S., Wong, R., Hickey, P., Pope, K., Wilson, G., Pébay, A., Davis, A., Petrou, S., Elefanty, A., Stanley, E., James, P., Macciocca, I., Bahlo, M., Cheung, M., Amor, D., Elliott, D., Lockhart, P. (2016) ALPK3 deficient cardiomyocytes generated from patient derived iPSCs and mutant hESCs display abnormal calcium handling and establish that ALPK3 deficiency underlies familial cardiomyopathy. European Heart Journal, 37(33):2586-90 (IF = 35.86) [Link]

  7. McCaughey, T., Liang, H., Chen, C., Fenwick, E., Rees, G., Wong, R., Vickers, J., Summers, M., MacGregor, C., Craig, J., Munsie, M., Pebay, A., Hewitt, A. (2016) An interactive multimedia approach to improving informed consent for induced pluripotent stem cell research. Cell Stem Cell, 18(3):307-8 (IF = 25.27) [Link]

  8. Pébay, A., Wong, R. (2016) Study of gap junctions in human embryonic stem cells. Methods in Molecular Biology, 1307:105-21.  [Link]

  9. Hernandez, D., Millard, R., Sivakumaran, P., Wong, R., Crombie, D., Hewitt, A., Liang, H., Hung, S., Pébay, A., Shepherd, R., Dusting, G., Lim, S.Y. (2016) Electrical stimulation promotes cardiac differentiation of human induced pluripotent stem cells. Stem Cells International, 2016;2016:1718041. (IF = 5.13) [Link]

  10. Lidgerwood, G., Ali, R., Lim, S.Y., Crombie, D., Gill, K., Hernandez, D., Kie, J., Conquest, A., Waugh, H., Wong, R, Liang, H., Hewitt, A., Davidson, K., Pébay, A. (2016) Defined medium conditions for the induction and expansion of human pluripotent stem cell-derived retinal pigment epithelium. Stem cell Reviews and Reports, 12(2):179-88 (IF = 6.69) [Link]


​Selected publications:

  1. Piao, Y., Hung, S., Lim, S., Wong, R.#, Ko, M#. (2014) Efficient generation of integration-free human induced pluripotent stem cells from keratinocytes by simple transfection of episomal vectors. Stem Cells Translational Medicine, 3(7): 787-91. # = equal last author. (IF = 7.66) [Link]

  2. Wong, R., Pollan, S., Fong, H., Ibrahim, H., Smith, E., Ho, M., Laslett, A., Donovan, P. (2011) A novel role for an RNA polymerase III subunit POLR3G in regulating pluripotency in human embryonic stem cells. Stem Cells, 29(10), 1517-1527. (IF = 5.85) [Link]

  3. Wong, R.#, Pera, M., Pébay, A. (2008) Role of gap junctions in embryonic and somatic stem cells. Stem Cell Reviews and Reports, 4: 283-292. (IF = 6.69) #=Corresponding author. [Link]

  4. Pébay, A.*, Wong, R.*, Pitson, S., Wolvetang, E., Peh, G., Filipczyk, A., Koh, K., Tellis, I., Nguyen, L. and Pera, M. (2005) Essential roles of sphingosine-1-phosphate and platelet-derived growth factor in the maintenance of human embryonic stem cells. Stem Cells, 23(10):1541-1548. * =  Equal first authors. (IF = 5.85) [Link]

  5. Wong, R.*, Pébay, A*., Nguyen, L., Koh, K. and Pera, M. (2004) Presence of functional gap junctions in human embryonic stem cells. Stem Cells, 22(6):883-889. * = Equal first authors. (IF = 5.85) [Link]

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